Vaccination with Dendritic Cell/Myeloma Fusion Post-Transplant for Multiple Myeloma

The BMT CTN 1401 study was designed as a Phase II, multicenter trial of vaccination with Dendritic Cell (DC)/myeloma fusions with granulocyte-macrophage colony-stimulating factor (GM-CSF) adjuvant plus lenalidomide maintenance therapy versus maintenance therapy alone or with GM-CSF following autologous transplant as part of upfront treatment of multiple myeloma. In this whitepaper, we compare the proportion of patients alive and in complete response at one-year post-transplant between patients receiving DC/myeloma vaccine/GM-CSF with lenalidomide maintenance therapy to those receiving lenalidomide maintenance therapy with or without GM-CSF.

What’s Inside:

• Outline of challenges and how they were overcome
• Trial outcome
• Highlights and achievements
• Success factors
• Key Data

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